G I Drugs
Many people with lupus suffer from gastrointestinal problems, especially heartburn caused by gastroesophageal reflux disease (GERD).
The gastrointestinal tract serves many important functions: digestive, excretory, endocrine, exocrine, and so on. These functions are the targets of several important classes of drugs. Some of these drugs have been discussed previously. This chapter mentions them and discusses in more detail others that do not fall into the
classes of agents described previously.
Ulceration and erosion of the lining of the upper portion of the gastrointestinal tract are common problems that manifest as gastroesophageal reflux disease (GERD), gastric and duodenal peptic ulcers, and stress-related mucosal injury. Drugs used in acid-peptic disease reduce intragastric acidity by manipulating systems controlling acid secretion, promote mucosal defense or, in the case of peptic ulcers, eradicate the bacterium Helicobacter pylori, which is detectable in over 80% of patients with duodenal ulcers.
These medications are used to treat people with heartburn, stomach or intestinal ulcers, or excess stomach acid. Proton pump inhibitors reduce acid by shutting down the tiny pumps within cells in your stomach that secrete it. Evidence also suggests that PPIs may inhibit Helicobacter pylori, a type of bacteria that can cause peptic ulcers, gastritis, and other gastrointestinal problems.
While taking any GI medication, you should avoid drinking alcohol, since it can further upset your stomach and cause an increase in the side effects of certain medications. In addition, tell your doctor about any other medications you may be taking, since certain drugs can interact with your GI medications.
Most PPIs come as over-the-counter or prescription tablets, but pantoprazole may also be given intravenously at the hospital for people who are admitted with a bleeding ulcer.
Antacids: Aluminum hydroxide, magnesium hydroxide, Calcium carbonate, Bismuth subsalicylate, Sodium bicarbonate
Proton Pump Inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Esomeprazole , Pantoprozole
Histamine2 Blockers: Cimetidine, Ranitidine hydrochloride, Famotidine, Nizatidine
Promotility Agents: Metoclopramide
RAGA-20: Superior Symptomatic Relief
Complete resolution of Ulcer pain
Indication: Duodenal Ulcer, Gastric ulcer, Zollinger – Ellison Syndrome, GERD RAGA-D: 94% patients rated ‘excellent or good’ relief as assessed by their physician
Improve the quality of life of patients
Indication: Peptic Ulcers, Hyperacidity, Zollinger – Ellison Syndrome, GERD SYSPAN-40: The right combination of complete dose of PPI with GI Prokinetic Agent
Results in better relief and thus quality of life
Indication: Hyperacidity, Drug induced gastritis SYSPAN-D: Suppresses acid release thus controls the symptoms of hyperacidity
Trusted combination with satisfactory clinical results
Indication: Heartburn, Hyperacidity, Peptic Ulcers