An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
The antifungals comprise a large and diverse group of drugs used to treat fungal infections. These agents are usually classified as either systemic or topical, although these divisions are somewhat arbitrary since many may be administered in either way. The mechanisms of action of antifungals include inhibition of fungal membrane and cell wall synthesis, alterations of fungal membranes, effects on microtubules, and inhibition of nucleic acid synthesis. Many of the systemic antifungals are toxic to mammalian cells, especially amphotericin B. Topical antifungals, in contrast, have little systemic toxicity because of poor absorption through the skin.
Antifungal drug resistance has become an increasing problem with the development of a larger compendium of antifungal agents. Drug resistance to the polyene antifungals is almost always primary resistance rather than secondary resistance. That is, the susceptibility profiles for the species are characteristic and inherent, and rarely change in response to exposure to the agent. For example, amphotericin B-resistant species such as Pseudallescheria boydii and Candida lusitaniae are well known, and do not appear to have originated from exposure to the antifungal. Despite decades of widespread clinical use of amphotericin B in Candida albicans infections, the development of secondary resistance has been exceedingly rare. In contrast, both primary and secondary resistance to 5-fluorocytosine are known to occur for strains of Candida species, serving as the basis for restricting use of this agent to combination therapy with other antifungal drugs.
Before taking antifungal medicines, speak to a pharmacist or your GP about:
Any existing conditions or allergies that may affect your treatment for fungal infection the possible side effects of antifungal medicines whether your antifungal medicine is suitable to take during pregnancy or while breastfeeding – many aren’t suitable
Antifungal medicines are available as:
- Topical antifungals – a cream, gel, ointment or spray you can apply directly to your skin, hair or nails
- Oral antifungals – a capsule, tablet or liquid medicine that you swallow
- Intravenous antifungals – an injection into a vein in your arm, usually given in hospital
- Intravaginal antifungal pessaries – small, soft tablets you can insert into the vagina
Sporys: Achieves high Clinical & Mycological Cure rates.
Extremely effective in wide range of superficial and systemic fungal infections
Indication: Systemic Fungal Infections, Dermatophytosis, Oral Thrush